Mesangial function and glomerular sclerosis in rats with aminonucleoside nephrosis
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چکیده
منابع مشابه
Changes in the molecular sieve of glomerular basement membrane in rats with aminonucleoside nephrosis.
Isolated and purified glomerular basement membranes (GBM) of normal and aminonucleoside (PAN) nephrosis rats were observed by electron microscopy after negative staining. Although GBM of normal rats appeared as a molecular sieve with uniform pores, GBM of nephrotic rats showed enlargement and elongation of the pores. For an average of fifty pores, the long dimension was 40.4+/-10.7 A and the sh...
متن کاملAminonucleoside Nephrosis
Experimental renal disease was produced in young rats by daily subcutaneous injections of 6-dimethylamino purine, 3-amino-d-ribose (aminonucleoside). The physiologic, biochemical, and light microscopic changes were similar to those observed in human nephrosis. Electron microscopy of the glomeruli from animals which received seven or more daily injections of aminonucleoside revealed characterist...
متن کاملModulation of glomerular endothelin and endothelin receptor gene expression in aminonucleoside-induced nephrosis.
This study assessed glomerular endothelin (ET)-1, ET-3, and ET-receptor A and B mRNA levels in puromycin aminonucleoside (PAN)-induced nephrosis. During the nephrotic stage, 8 days after PAN injection, ET-1 and ETB receptor mRNA were elevated by 2.8 +/- 0.8-fold (P < 0.01) and 2.4 +/- 0.9-fold (P < 0.01), respectively, as compared with controls. These mRNA levels decreased to control levels by ...
متن کاملAn Ultrastructural Study of Glomerular Permeability in Aminonucleoside Nephrosis Using Catalase as a Tracer Protein
Beef liver catalase (mol wt 240,000) was injected intravenously into normal rats and rats made nephrotic with aminonucleoside of puromycin. The localization of the tracer in the kidneys was then studied by ultrastructural cytochemistry, 3 min-12 hr after injection. Passage of catalase into the urinary space in normal rats was restricted by the basement membrane and by the epithelial slit pore. ...
متن کاملOsteopontin in chronic puromycin aminonucleoside nephrosis.
Increased expression of osteopontin (OPN) associated with interstitial monocyte infiltration has been demonstrated in the early phase of a variety of experimental renal diseases. Whether these changes occur in the chronic phase of progressive glomerular disease is unknown. Chronic puromycin aminonucleoside nephrosis (PAN) was induced in 16 rats by the injection of a single bolus of PA into the ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1985
ISSN: 0085-2538
DOI: 10.1038/ki.1985.24